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Robotics

Meet Two Startups Bringing Robots to Restaurants (seattletimes.com)

It's a coffee shop and and robotics startup. Founded in 2020, Seattle-based Artly has seven locations in Washington, Oregon and California, reports the Seattle Times, noting that each location has a mechanically dexterous robotic arm that they're calling a "barista bot" that "makes the espresso, pours the milk, steams the foam and puts it all together, topping it off with a carefully drawn foam leaf." [P]ressing market needs were behind the innovation. Cost concerns and high employee turnover in food services have led Artly and others to provide automated solutions to restaurants and businesses, even before the pandemic hit and brought additional challenges. Just a couple of years into operation, Artly CEO Meng Wang said the company has maintained healthy operating margins — the profit a company makes after paying for costs of production — by eliminating the biggest expense in food business: labor. For a coffee shop that would need two or three baristas, Artly needs one staffer, in addition to a barista bot like Jarvis. Artly reinvests the money it saves from labor into sourcing more quality coffee, Wang said.

Artly isn't alone in introducing robot help in food preparation. Another Seattle-based startup, Picnic, offers automation solutions for a staple of the American diet: pizza. Its food prep station can produce up to 100 pizzas in one hour using metered toppings. Since Picnic was founded in 2016, its robots have assembled pizzas in many places, including Seattle's T-Mobile Park and the Las Vegas Convention Center. The company has seen a growing interest in its robots. This summer, Picnic announced partnerships with pizzeria Moto's West Seattle location and a Domino's store in Berlin.... With a robotics-as-a-service business model, the standard full offering for operators is $4,500 a month on a 36-month contract.

But the founder also told the newspaper how their customers reacted to their barista bots: [C]ustomers were initially intrigued and excited about the robot barista, but the service was slower than with a human barista. He said customers craved the connection with the person making their coffee. "When [customers] go to the coffee shop, their expectation is to be served by a human," Yang said.

With that, Artly has focused on opening locations in shopping malls and business office buildings rather than standard coffee shops.

Power

In Fusion Breakthrough, US Scientists Reportedly Produce Reaction With Net Energy Gain (independent.co.uk) 36

"U.S. scientists have reportedly carried out the first nuclear fusion experiment to achieve a net energy gain," reports the Independent, "a major breakthrough in a field that has been pursuing such a result since the 1950s, and a potential milestone in the search for a climate-friendly, renewable energy source to replace fossil fuels." The experiment took place in recent weeks at the government-funded Lawrence Livermore National Laboratory in California, where researchers used a process known as inertial confinement fusion, the Financial Times reports, citing three people with knowledge of the experiment's preliminary results. The test involved bombarding a pellet of hydrogen plasma with the world's largest laser to trigger a nuclear fusion reaction, the same process which takes place in the sun.

Researchers were able to produce 2.5 megajoules of energy, 120 per cent of the 2.1 megajoules used to power the experiment. The laboratory confirmed to the FT it had recently conducted a "successful" experiment at the National Ignition Facility, but declined to comment further, citing the preliminary nature of the data....

"Scientists have struggled to show that fusion can release more energy out than is put in since the 1950s, and the researchers at Lawrence Livermore seem to have finally and absolutely smashed this decades-old goal," Arthur Turrell, deputy director of the UK Office for National Statistics, wrote on Twitter on Sunday. "This experimental result will electrify efforts to eventually power the planet with nuclear fusion — at a time when we've never needed a plentiful source of carbon-free energy more!"

But "the resources needed to recreate the reaction on the scale required to make fusion practical for energy production are immense," reports the Washington Post: More importantly, engineers have yet to develop machinery capable of affordably turning that reaction into electricity that can be practically deployed to the power grid. Building devices that are large enough to create fusion power at scale, scientists say, would require materials that are extraordinarily difficult to produce. At the same time, the reaction creates neutrons that put a tremendous amount of stress on the equipment creating it, such that it can get destroyed in the process. And then there is the question of whether the technology could be perfected in time to make a dent in climate change.

Even so, researchers and investors in fusion technology hailed the breakthrough as an important advancement.

Programming

Linux 6.1 Released With Initial Support for Rust-Based Kernel Development (lwn.net) 11

"Linus has released the 6.1 kernel," reports LWN.net — and it's the one with initial support for kernel development in Rust.

Elsewhere LWN explains the specifics of this milestone: No system with a production 6.1 kernel will be running any Rust code, but this change does give kernel developers a chance to play with the language in the kernel context and get a sense for how Rust development feels....

There are other initiatives underway, including the writing of an Apple graphics driver in the Rust language. For the initial merge into the mainline kernel, though, Linus Torvalds made it clear that as little functionality as possible should be included. So those drivers and their support code were trimmed out and must wait for a future kernel release. What is there is the support needed to build a module that can be loaded into the kernel, along with a small sample module.... Torvalds asked for something that could do "hello world" and that is what we got. It is something that can be played with, but it cannot be used for any sort of real kernel programming at this point.

That situation will, hopefully, change in the near future.

Meanwhile, Linux 6.1 also includes "support for destructive BPF programs, some significant io_uring performance improvements, better user-space control over transparent huge-page creation, improved memory-tiering support."

The Register adds: Other interesting additions include more support for the made-in-China LoongArch CPU architecture, introductory work to support Wi-Fi 7 and security fixes for some flaky Wi-Fi routines in previous versions of the kernel. There's also plenty of effort to improve the performance of Linux on laptops, and enhanced power efficiency for AMD's PC-centric RYZEN silicon.
Unix

OSnews Decries 'The Mass Extinction of Unix Workstations' (osnews.com) 115

Anyone remember the high-end commercial UNIX workstations from a few decades ago — like from companies like IBM, DEC, SGI, and Sun Microsystems?

Today OSnews looked back — but also explored what happens when you try to buy one today> : As x86 became ever more powerful and versatile, and with the rise of Linux as a capable UNIX replacement and the adoption of the NT-based versions of Windows, the days of the UNIX workstations were numbered. A few years into the new millennium, virtually all traditional UNIX vendors had ended production of their workstations and in some cases even their associated architectures, with a lacklustre collective effort to move over to Intel's Itanium — which didn't exactly go anywhere and is now nothing more than a sour footnote in computing history.

Approaching roughly 2010, all the UNIX workstations had disappeared.... and by now, they're all pretty much dead (save for Solaris). Users and industries moved on to x86 on the hardware side, and Linux, Windows, and in some cases, Mac OS X on the software side.... Over the past few years, I have come to learn that If you want to get into buying, using, and learning from UNIX workstations today, you'll run into various problems which can roughly be filed into three main categories: hardware availability, operating system availability, and third party software availability.

Their article details their own attempts to buy one over the years, ultimately concluding the experience "left me bitter and frustrated that so much knowledge — in the form of documentation, software, tutorials, drivers, and so on — is disappearing before our very eyes." Shortsightedness and disinterest in their own heritage by corporations, big and small, is destroying entire swaths of software, and as more years pass by, it will get ever harder to get any of these things back up and running.... As for all the third-party software — well, I'm afraid it's too late for that already. Chasing down the rightsholders is already an incredibly difficult task, and even if you do find them, they are probably not interested in helping you, and even if by some miracle they are, they most likely no longer even have the ability to generate the required licenses or release versions with the licensing ripped out. Stuff like Pro/ENGINEER and SoftWindows for UNIX are most likely gone forever....

Software is dying off at an alarming rate, and I fear there's no turning the tide of this mass extinction.

The article also wonders why companies like HPE don't just "dump some ISO files" onto an FTP server, along with patch depots and documentation. "This stuff has no commercial value, they're not losing any sales, and it will barely affect their bottom line.
Medicine

Teenager's Incurable Cancer Cleared With Revolutionary DNA-Editing Technique (bbc.com) 49

"A teenage girl's incurable cancer has been cleared from her body," reports the BBC, "in the first use of a revolutionary new type of medicine...." Doctors at Great Ormond Street Hospital used "base editing" to perform a feat of biological engineering to build her a new living drug. Six months later the cancer is undetectable, but Alyssa is still being monitored in case it comes back.

Alyssa, who is 13 and from Leicester, was diagnosed with T-cell acute lymphoblastic leukaemia in May last year.... Her cancer was aggressive. Chemotherapy, and then a bone-marrow transplant, were unable to rid it from her body.... The team at Great Ormond Street used a technology called base editing, which was invented only six years ago [which] allows scientists to zoom to a precise part of the genetic code and then alter the molecular structure of just one base, converting it into another and changing the genetic instructions. The large team of doctors and scientists used this tool to engineer a new type of T-cell that was capable of hunting down and killing Alyssa's cancerous T-cells....

After a month, Alyssa was in remission and was given a second bone-marrow transplant to regrow her immune system.... Alyssa is just the first of 10 people to be given the drug as part of a clinical trial.

Her mother said that a year ago she'd been dreading Christmas, "thinking this is our last with her". But it wasn't.

And the BBC adds that applying the technology to cancer "only scratches the surface of what base editing could achieve.... There are already trials of base editing under way in sickle-cell disease, as well as high cholesterol that runs in families and the blood disorder beta-thalassemia."
Science

Why the Laws of Physics Don't Actually Exist (newscientist.com) 115

Theoretical physicist Sankar Das Sarma wrote a thought-provoking essay for New Scientist magazine's Lost in Space-Time newsletter: I was recently reading an old article by string theorist Robbert Dijkgraaf in Quanta Magazine entitled "There are no laws of physics". You might think it a bit odd for a physicist to argue that there are no laws of physics but I agree with him. In fact, not only do I agree with him, I think that my field is all the better for it. And I hope to convince you of this too.

First things first. What we often call laws of physics are really just consistent mathematical theories that seem to match some parts of nature. This is as true for Newton's laws of motion as it is for Einstein's theories of relativity, Schrödinger's and Dirac's equations in quantum physics or even string theory. So these aren't really laws as such, but instead precise and consistent ways of describing the reality we see. This should be obvious from the fact that these laws are not static; they evolve as our empirical knowledge of the universe improves.

Here's the thing. Despite many scientists viewing their role as uncovering these ultimate laws, I just don't believe they exist.... I know from my 40 years of experience in working on real-life physical phenomena that the whole idea of an ultimate law based on an equation using just the building blocks and fundamental forces is unworkable and essentially a fantasy. We never know precisely which equation describes a particular laboratory situation. Instead, we always have to build models and approximations to describe each phenomenon even when we know that the equation controlling it is ultimately some form of the Schrödinger equation!

Even with quantum mechanics, space and time are variables that have to be "put in by hand," the article argues, "when space and time should come out naturally from any ultimate law of physics. This has remained perhaps the greatest mystery in fundamental physics with no solution in sight...."

"It is difficult to imagine that a thousand years from now physicists will still use quantum mechanics as the fundamental description of nature.... I see no particular reason that our description of how the physical universe seems to work should reach the pinnacle suddenly in the beginning of the 21st century and become stuck forever at quantum mechanics. That would be a truly depressing thought...!"

"Our understanding of the physical world must continue indefinitely, unimpeded by the search for ultimate laws. Laws of physics continuously evolve — they will never be ultimate."

Thanks to long-time Slashdot reader InfiniteZero for sharing the article!
EU

WSJ: Europe, US Need Grand Bargain on Chips and EVs to Counter China (bangkokpost.com) 41

South Korea, Japan and the EU see America's electric-vehicle subsidies as discriminating against non-American manufacturers, and are "rebuffing" restrictions on exporting sensitive semiconductor technology to China, reports the Wall Street Journal. (Alternate URL here.)

The EU's executive arm complains that newly-passed U.S. subsidies constitute "a market-distorting boost, tilting the global level playing field and turning a common global objective — fighting climate change — into a zero-sum game." There's a grand bargain to be had here: the U.S. makes its allies eligible for its EV subsidies and those allies join its semiconductor controls. The politics and details of any such bargain are, of course, difficult, maybe insurmountable. Yet such an accommodation, if it happened, would entail almost no economic cost to the U.S. or its allies — and potentially large long-term gains....

The U.S. Treasury Department could use its administrative discretion to phase in the Inflation Reduction Act's provisions or define content to allow more of these manufacturers' products to qualify. It could also interpret "free-trade agreement" to include not just formal bilateral treaties but broader pacts such as the WTO Government Procurement Agreement or the Minerals Security Partnership, both of which include Japan, South Korea, and the European Union but not mainland China or Russia.

If the U.S. bends to its allies on electric vehicles, its allies should bend to the U.S. on semiconductors.... Meanwhile, business as usual entails its own — potentially significant — costs. China's long-term goal is self sufficiency in all advanced technology, including semiconductors. It does business with Western companies until its own national champions can displace them first in China and then abroad. It has already followed the script in high-speed rail, power generation and telecommunications equipment. If China has its way, the market share that South Korean, Japanese and European semiconductor companies are trying to preserve will be gone a few decades from now.

Social Networks

Is This Nature App the Key To Saving Civilization? (buffalonews.com) 45

Slashdot reader biobricks shares this report from the New York Times. (Alternate URLs here and here.) When Merav Vonshak wanted to identify the gelatinous blob she had photographed floating in a shallow pool of water on a family vacation, she bypassed a wildlife-related website too often beset by bickering. She gave no consideration to brand-name social media platforms known for snark or misinformation.

Instead she uploaded the picture to a site called iNaturalist, where strangers have come together to pursue a very specific type of truth: the correct scientific classification for the living things they photograph in the wild or the backyard. They have so far processed about 90 million, with at least a quarter completed in 2022 alone.... Like many iNaturalist users, Dr. Vonshak, 45, invokes utopian metaphors not typically associated with social media to describe the platform. ("It reminds me of "Star Trek," you know? Our society as I would wish it would be.") Indeed, while examining mud snakes and mosses, it has dawned on many of the iNaturalist faithful that maybe they are on to something much bigger — a model for using the web that is governed by cooperation, not combat....

A not-for-profit initiative of the California Academy of Sciences and the National Geographic Society, iNaturalist says it aims to connect people to nature through technology. And the site's species-level identifications have been cited in thousands of scientific papers. But in a moment that can feel like everything is subject to dispute — the cause of inflation, the nature of gender, the legitimacy of an election — iNaturalist has also gained recognition as a rare place on the internet where people with different points of view manage to forge agreement on what constitutes reality.... And some social network scholars say its growth holds lessons for improved communication....

With help from a computer-vision algorithm, users who upload an observation typically suggest an identification. Others can then add their own nomination in the comments. As soon as a two-thirds majority emerges, the record receives a "community ID," which can be overwritten anytime the majority shifts.... The growth of iNaturalist has been fueled in part by technologies that have democratized the act of documenting and identifying species. Its machine-learning algorithm, trained on the identifications of iNaturalist users over the last decade, now reliably recognizes some 70,000 types of organisms and provides real-time suggestions. Better smartphone cameras have helped, as have inexpensive macro-lens attachments and the ubiquity of wireless internet access.

But the article also applauds the site's "explicit aim of collaboration and consensus" — 120 million "observations" have been posted just this year — each a chance to experience one more small collective triumph.

In the article one 32-year-old describes the site as "the place where I feel like I interact with strangers and work towards the common good."
Data Storage

Linux Kernel Fixes Longstanding Bug in Its Handling of Floppy Disks (theregister.com) 46

"Linux kernel 6.2 should contain fixes for some problems handling floppy disks," reports the Register, "a move which shows that someone somewhere is still using them." This isn't the only such fix in recent years. As a series of articles on Phoronix details, there has been a slow but steady flow of fixes for the kernel's handling of floppy drives since at least kernel 5.17, as The Register mentioned when it came out....

Back in July 2016, SUSE kernel developer Jiri Kosina submitted a patch. The problem arose because this change broke something else and later got reverted, and so the problem hung around. In July last year, he sent in a new patch that fixed it again for the 5.12 kernel, and was later back-ported to 5.10, an LTS version, and again into kernel 5.15 — another an LTS version, and the one you're running today if you're on the current Ubuntu LTS release, or something built from it such as Linux Mint 21....

Now, in December 2022, a new patch for the forthcoming kernel 6.2 fixes a memory leak that dates back to 5.11 or before.

Moon

After 25 Days in Space, NASA's Orion Moon Capsule Successfully Splashes Down (nasa.gov) 36

Splashdown successful. The announcer on NASA's livestream called it a "text-book entry" for "America's new ticket to ride -- to the moon and beyond."

After flying over 239,000 miles — and 80 miles over the surface of the moon — NASA's uncrewed "Orion" capsule has returned from its 25-and-a-half day test flight in space.

NASA is still streaming its coverage. And CNN had emphasized that "This final step will be among the most important and dangerous legs of the mission." "We're not out of the woods yet. The next big test is the heat shield," NASA Administrator Bill Nelson told CNN in a phone interview Thursday, referring to the barrier designed to protect the Orion capsule from the excruciating physics of reentering the Earth's atmosphere. The spacecraft will be traveling about 32 times the speed of sound (24,850 miles per hour or nearly 40,000 kilometers per hour) as it hits the air — so fast that compression waves will cause the outside of the vehicle to heat to about 5,000 degrees Fahrenheit (2,760 degrees Celsius)....

As the capsule reaches around 200,000 feet (61,000 meters) above the Earth's surface, it will perform a roll maneuver that will briefly send the capsule back upward — sort of like skipping a rock across the surface of a lake.... "By dividing the heat and force of reentry into two events, skip entry also offers benefits like lessening the g-forces astronauts are subject to," said Joe Bomba, Lockheed Martin's Orion aerosciences aerothermal lead, in a statement....

As it embarks on its final descent, the capsule will slow down drastically, shedding thousands of miles per hour in speed until its parachutes deploy. By the time it splashes down, Orion will be traveling 20 miles per hour (32 kilometers per hour). While there are no astronauts on this test mission — just a few mannequins equipped to gather data and a Snoopy doll — Nelson, the NASA chief, has stressed the importance of demonstrating that the capsule can make a safe return.

The Almighty Buck

Sam Bankman-Fried: I Hope to Make Money to Pay People Back (bbc.com) 116

"Disgraced crypto boss Sam Bankman-Fried says he hopes to start a new business to make enough money to pay back victims of the FTX collapse," reports the BBC: Speaking in a luxury complex in the Bahamas, the former billionaire denies fraud but says he was "not nearly as competent as I thought I was".... It is estimated that more than a million FTX users are locked out of their crypto wallets and cannot access their funds.

Mr Bankman-Fried invited the BBC to the residential complex in the Bahamas where he still lives and said he hopes to find a way to pay back FTX users. "I'm going to be thinking about how we can help the world and if users haven't gotten much back, I'm going to be thinking about what I can do for them. And I think at the very least I have a duty to FTX users to do right by them as best as I can," he told me.

Asked if he planned to start a new business venture to earn the money to pay investors back, he said: "I would give anything to be able to do that. And I'm going to try if I can."

Bankman-Friedman also said that while "ruminating at night," he also worries about being arrested.
IT

No, Remote Employees Aren't Becoming Less Engaged (hbr.org) 91

"Employees have gotten more — not less — engaged over the past three years since remote work became the norm for many knowledge workers," argues an assistant professor of management from the business school at the University of Texas at Austin. He'd teamed up with a software company providing analytics to large corporations to measure the number of spontaneously-happening individual remote meetings: Given the anecdotal evidence of workers recently disengaging or quiet quitting, we had originally predicted that one of the easiest ways to observe this effect would be a continual decrease in the number of times remote or hybrid coworkers were engaging — or meeting — with each other. However, we found quite the opposite.

To more deeply explore the nature of how remote collaboration is changing over time, we gathered metadata from all Zoom, Microsoft Teams, and Webex meetings (involving webcams on and/or off) from 10 large global organizations (seven of which are Fortune 500 firms) spanning a variety of fields, including technology, health care, energy, and financial services. Specifically, we compared six-week snapshots of raw meeting counts from April through mid-May in 2020 following the Covid-19 lockdowns, and the same set of six weeks in 2021 and 2022.... This dataset resulted in a total of more than 48 million meetings for more than half a million employees....

In 2020, 17% of meetings were one-on-one, but in 2022, 42% of meetings were one-on-one... In 2020, only 17% of one-on-one meetings were unscheduled, but in 2022, 66% of one-on-one meetings were unscheduled. Furthermore, the growth in one-on-one meetings between 2020 and 2022 was almost solely due to the increase in unscheduled meetings (whereas scheduled meetings remained relatively constant)... The combination of these findings presents an interesting picture: not that remote workers seem to be becoming less engaged, but rather — at least with respect to meetings — they are becoming more engaged with their colleagues.

This data also suggests that remote interactions are shifting to more closely mirror in-person interactions. Whereas there have been substantial concerns that employees are missing out on the casual and spontaneous rich interactions that happen in-person, these findings indicate that remote employees may be beginning to compensate for the loss of those interactions by increasingly having impromptu meetings remotely.

Earth

'The 10 Most Promising Breakthrough Innovations of 2022' (theatlantic.com) 55

This week the Atlantic published its list of "the 10 Most Promising Breakthrough Innovations of 2022."

"We didn't just get one 'unheard-of' cancer breakthrough; we got several in one year...." Is death reversible? It was this year for several pigs (or, at least, for their organs). By pumping an experimental substance into the veins and arteries of animals that had been lying deceased for an hour, Yale researchers got their hearts to start beating again. The technology is "very far away from use in humans," Stephen Latham, a bioethicist at Yale University, told The New York Times. In the short term, scientists said, they hope that their research could help doctors preserve the organs of the recently deceased for use in transplants. But the longer-term implications of the experiment can't be ignored: If we have the power to reanimate the heart or other organs of the recently deceased, at what point might we be able to reverse sudden deaths? Could we revive soldiers who bleed out on the battlefield? Could we stock hospitals and nursing homes with buckets of the stuff to resuscitate patients? Should every future American household keep some on hand in the event of a terrible accident?

These questions thrust us into the ethical realm and invoke spooky references to "The Monkey's Paw," Pet Sematary, and any number of stories about the dark side of trying to design an escape hatch from mortality. Perhaps, as this technology improves, that debate is on its way. But for millions of people who have lost loved ones to, say, a sudden heart attack or stroke, it's not remotely dystopian to imagine an injection that could reverse tragedies long considered irreversible....

The Power to Synthesize Life (Kind Of)
This summer, scientists grew an embryo in a lab without the use of sperm, or eggs, or a womb. It happened to be that of a mouse. But the species is of secondary importance.... Some scientists I consulted for this project said that the results, which were published this year in the science journal Cell, were the most important scientific breakthrough of 2022.

Scientists are not close to turning stem cells into human babies that make their first gasping cries in antiseptic laboratories. But this work does suggest a major leap forward in our ability to grow synthetic organs and more closely research the relationship between embryonic mutations and developmental diseases. As Paul Tesar, a developmental biologist at Case Western Reserve University School of Medicine, told Stat, "As soon as the science starts to move into a place where it's feasible to go from a stem cell population in a Petri dish all the way through to organ development, it's a pretty wild and remarkable time."

The article also notes that NuScale's small nuclear reactors received approval from the U.S. Nuclear Regulatory Commission, and "could be running by the end of the decade." Meanwhile, the start-up Quaise is working on drilling technology "that can vaporize granite with a highly concentrated beam of radio-frequency power. If such a technology became widely available, deep drilling would be commonplace and geothermal energy would be accessible on just about any patch of land. It would be as though humankind conceived of a magic wand that, waved across the Earth, makes any square mile as energy-rich as an oil-gushing stretch of Texas or Saudi Arabia."

The article also suggests one more possibility for the future. "Decades from now, millions of people may actually prefer the consistency and taste of meat that didn't come from an animal, because they'll know what they're buying when a cultivated rib eye is as consistent as an electrical gadget."
Medicine

What Causes Alzheimer's? Scientists Are Rethinking the Answer (quantamagazine.org) 37

"After decades in the shadow of the reigning model for Alzheimer's disease, alternative explanations are finally getting the attention they deserve," writes Quanta magazine — in a 10,000-word update on where we are now: Three decades ago, scientists thought they had cracked the medical mystery of what causes Alzheimer's disease with an idea known as the amyloid cascade hypothesis. It accused a protein called amyloid-beta of forming sticky, toxic plaques between neurons, killing them and triggering a series of events that made the brain waste away.... Decades of work and billions of dollars went into funding clinical trials of dozens of drug compounds that targeted amyloid plaques. Yet almost none of the trials showed meaningful benefits to patients with the disease....

A stream of recent findings has made it clear that other mechanisms may be at least as important as the amyloid cascade as causes of Alzheimer's disease.... The emerging new models of the disease are more complex than the amyloid explanation, and because they are still taking shape, it's not clear yet how some of them may eventually translate into therapies. But because they focus on fundamental mechanisms affecting the health of cells, what's being learned about them might someday pay off in new treatments for a wide variety of medical problems, possibly including some key effects of aging.... While these alternate ideas were once hushed and thrown under the rug, now the field has broadened its attention.

The article explores the theory — derived from research on genetically-engineered mice — that neurons bulging with toxic accumulations of proteins and molecules could be mistaken for classic amyloid plaques outside cells. (But in fact "the extracellular amyloid plaques weren't killing the cells — because the cells were already dead.") Scientists are now also investigating lysosomes, cholesterol metabolism, and even the immune system.

To say that the amyloid hypothesis is dead would be overstating it, said Donald Weaver, a co-director of the Krembil Brain Institute in Toronto, but "I would say that the amyloid hypothesis is insufficient...."

By 2017, 146 drug candidates for treating Alzheimer's disease had been deemed unsuccessful. Only four drugs had been approved, and they treated the symptoms of the disease, not its underlying pathology. The results were so disappointing that in 2018, Pfizer pulled out of Alzheimer's research. A 2021 review that compared the results of 14 of the major trials confirmed that reducing extracellular amyloid did not greatly improve cognition....

The hypothesis took another hit last July when a bombshell article in Science revealed that data in the influential 2006 Nature paper linking amyloid plaques to cognitive symptoms of Alzheimer's disease may have been fabricated. The connection claimed by the paper had convinced many researchers to keep pursuing amyloid theories at the time.

Earth

US Lawmakers Accuses Big Oil of a Long-Running Climate Disinformation Campaign (cnn.com) 97

A year-long investigation by a Congressional commitee is accussing the fossil fuel industry of spreading climate disinformation. CNN reports: The committee found the fossil fuel industry is "posturing on climate issues while avoiding real commitments" to reducing greenhouse gas emissions. Lawmakers said it has sought to portray itself as part of the climate solution, even as internal industry documents reveal how companies have avoided making real commitments. "Today's documents reveal that the industry has no real plans to clean up its act and is barreling ahead with plans to pump more dirty fuels for decades to come," House Oversight Committee Chair Carolyn Maloney told CNN in a statement....

The committee said documents uncovered also showed the fossil fuel industry has presented natural gas as a so-called "bridge fuel" to transition to cleaner sources of energy, all while doubling down on its long-term reliance on fossil fuels with no clear plan of action to fully transition to clean energy....

In a 2016 email from a BP executive to John Mingé, then-Chairman and President of BP America, and others, about climate and emissions, an employee assessed that the company often adopted an obstructionist strategy with regulators, noting, "we wait for the rules to come out, we don't like what we see, and then try to resist and block."

"The fossil fuel industry has of late been involved in extensive "greenwashing" — misleading claims in advertisements, particularly on social media, claiming or suggesting that they are "Paris aligned," and that they are committed to meaningful solutions," Naomi Oreskes, a Harvard professor who has studied the fossil fuel industry's rebuke of climate science and consulted for law firms that have brought suits against the fossil fuel industry, told CNN. "Numerous analyses shows that these claims are untrue."

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